Drug interactions
Nafcillin + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Major
Nafcillin and Sofosbuvir-velpatasvir-voxilaprevir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and possibly P-gp, which may reduce velpatasvir, voxilaprevir and sofosbuvir exposure. This may compromise HCV treatment efficacy.
What this interaction means in plain words
Nafcillin and Sofosbuvir-velpatasvir-voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nafcillin induces CYP3A4 and P-gp, which increases clearance of the HCV drugs.
What to do
Avoid combining where possible; use a non-inducing antibiotic such as a cephalosporin or defer HCV therapy. If unavoidable, monitor HCV RNA for response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Nafcillin with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as major. Nafcillin and Sofosbuvir-velpatasvir-voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nafcillin induces CYP3A4 and possibly P-gp, which may reduce velpatasvir, voxilaprevir and sofosbuvir exposure. This may compromise HCV treatment efficacy.
How serious is the interaction between Nafcillin and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; use a non-inducing antibiotic such as a cephalosporin or defer HCV therapy. If unavoidable, monitor HCV RNA for response.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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