Drug interactions
Nafcillin + Solifenacin
Severity: Minor
Nafcillin and Solifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and may lower solifenacin exposure, reducing its effect on overactive bladder symptoms. The effect is likely to be temporary during antibiotic therapy.
What this interaction means in plain words
Nafcillin and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 induction by nafcillin increases solifenacin clearance.
What to do
Monitor for reduced symptom control during nafcillin therapy and reassess the solifenacin dose after the antibiotic course ends.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Nafcillin with Solifenacin?
MediHelp rates the interaction as minor. Nafcillin and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin induces CYP3A4 and may lower solifenacin exposure, reducing its effect on overactive bladder symptoms. The effect is likely to be temporary during antibiotic therapy.
How serious is the interaction between Nafcillin and Solifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control during nafcillin therapy and reassess the solifenacin dose after the antibiotic course ends.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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