Drug interactions
Nalbuphine + Selegiline
Severity: Moderate
Nalbuphine and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with MAO inhibitors can cause CNS depression, hypotension and occasionally serotonergic or excitatory reactions. This is best documented with meperidine; nalbuphine data are limited and the risk is predicted from class effects.
What this interaction means in plain words
Nalbuphine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nalbuphine belongs to Musculoskeletal; Selegiline belongs to Central Nervous System.
Why it happens
Additive CNS and hemodynamic effects; the mechanism with nalbuphine is not well established.
What to do
Use the lowest effective nalbuphine dose and monitor sedation, respiratory rate and blood pressure. Watch for signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Frequently asked questions
Can I take Nalbuphine with Selegiline?
MediHelp rates the interaction as moderate. Nalbuphine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids combined with MAO inhibitors can cause CNS depression, hypotension and occasionally serotonergic or excitatory reactions. This is best documented with meperidine; nalbuphine data are limited and the risk is predicted from class effects.
How serious is the interaction between Nalbuphine and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective nalbuphine dose and monitor sedation, respiratory rate and blood pressure. Watch for signs of serotonin toxicity.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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