Drug interactions
Naldemedine + Netupitant-palonosetron
Severity: Moderate
Naldemedine and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is cleared partly by CYP3A4, so netupitant may increase its exposure. This could heighten gastrointestinal effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Naldemedine and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naldemedine belongs to Gastrointestinal Tract; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
Netupitant inhibits CYP3A4, reducing naldemedine clearance.
What to do
Monitor for gastrointestinal adverse effects such as abdominal pain and diarrhea; no dose change is routinely required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Naldemedine and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naldemedine is cleared partly by CYP3A4, so netupitant may increase its exposure. This could heighten gastrointestinal effects such as abdominal pain and diarrhea.
How serious is the interaction between Naldemedine and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects such as abdominal pain and diarrhea; no dose change is routinely required.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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