Drug interactions
Naldemedine + Nilotinib
Severity: Minor
Naldemedine and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein and may increase naldemedine exposure. This may increase gastrointestinal adverse effects such as abdominal pain and diarrhea, or opioid withdrawal symptoms.
What this interaction means in plain words
Naldemedine and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naldemedine belongs to Gastrointestinal Tract; Nilotinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux of naldemedine by nilotinib.
What to do
Monitor for gastrointestinal effects and opioid withdrawal symptoms. No empirical dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Nilotinib?
MediHelp rates the interaction as minor. Naldemedine and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib inhibits P-glycoprotein and may increase naldemedine exposure. This may increase gastrointestinal adverse effects such as abdominal pain and diarrhea, or opioid withdrawal symptoms.
How serious is the interaction between Naldemedine and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal effects and opioid withdrawal symptoms. No empirical dose change is usually needed.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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