Drug interactions
Naldemedine + Quinine
Severity: Minor
Naldemedine and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine inhibits P-glycoprotein and may raise naldemedine concentrations. This could increase gastrointestinal adverse effects such as abdominal pain and diarrhea or opioid withdrawal symptoms.
What this interaction means in plain words
Naldemedine and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naldemedine belongs to Gastrointestinal Tract; Quinine belongs to Anti Parasitic.
Why it happens
P-gp inhibition by quinine increases naldemedine absorption and reduces its efflux.
What to do
Monitor for abdominal pain, diarrhea and withdrawal symptoms. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Quinine?
MediHelp rates the interaction as minor. Naldemedine and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinine inhibits P-glycoprotein and may raise naldemedine concentrations. This could increase gastrointestinal adverse effects such as abdominal pain and diarrhea or opioid withdrawal symptoms.
How serious is the interaction between Naldemedine and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal pain, diarrhea and withdrawal symptoms. No dose change is usually needed.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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