Drug interactions
Naldemedine + Sofosbuvir-velpatasvir
Severity: Minor
Naldemedine and Sofosbuvir-velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is a substrate of CYP3A4 and P-gp, and velpatasvir inhibits P-gp. Exposure may rise, increasing opioid-withdrawal-like gastrointestinal effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Naldemedine and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naldemedine belongs to Gastrointestinal Tract; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Velpatasvir inhibits P-gp and weakly CYP3A4, increasing naldemedine absorption and reducing its clearance.
What to do
Monitor for abdominal pain, diarrhea and opioid-withdrawal symptoms. No dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as minor. Naldemedine and Sofosbuvir-velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is a substrate of CYP3A4 and P-gp, and velpatasvir inhibits P-gp. Exposure may rise, increasing opioid-withdrawal-like gastrointestinal effects such as abdominal pain and diarrhea.
How serious is the interaction between Naldemedine and Sofosbuvir-velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal pain, diarrhea and opioid-withdrawal symptoms. No dose change is usually required.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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