Drug interactions
Naldemedine + Sunitinib
Severity: Minor
Naldemedine and Sunitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib may inhibit P-glycoprotein and raise naldemedine exposure. This could increase opioid-withdrawal-like gastrointestinal effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Naldemedine and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naldemedine belongs to Gastrointestinal Tract; Sunitinib belongs to Oncology.
Why it happens
Possible inhibition of P-gp mediated efflux of naldemedine by sunitinib.
What to do
No dose change is generally needed; monitor for abdominal pain, diarrhea or opioid withdrawal symptoms and reassess naldemedine if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Sunitinib?
MediHelp rates the interaction as minor. Naldemedine and Sunitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sunitinib may inhibit P-glycoprotein and raise naldemedine exposure. This could increase opioid-withdrawal-like gastrointestinal effects such as abdominal pain and diarrhea.
How serious is the interaction between Naldemedine and Sunitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for abdominal pain, diarrhea or opioid withdrawal symptoms and reassess naldemedine if they occur.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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