Drug interactions
Naldemedine + Tamoxifen
Severity: Minor
Naldemedine and Tamoxifen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tamoxifen inhibits P-glycoprotein and may increase naldemedine exposure. This may increase gastrointestinal adverse effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Naldemedine and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Naldemedine belongs to Gastrointestinal Tract; Tamoxifen belongs to Endocrine.
Why it happens
Tamoxifen inhibits P-gp efflux of naldemedine.
What to do
Monitor for gastrointestinal adverse effects; no dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Tamoxifen?
MediHelp rates the interaction as minor. Naldemedine and Tamoxifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tamoxifen inhibits P-glycoprotein and may increase naldemedine exposure. This may increase gastrointestinal adverse effects such as abdominal pain and diarrhea.
How serious is the interaction between Naldemedine and Tamoxifen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects; no dose change is needed.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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