Drug interactions
Naproxen + Nebivolol
Severity: Moderate
Naproxen and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen may weaken the antihypertensive effect of nebivolol, particularly with sustained use. The effect is usually modest but can be relevant in poorly controlled hypertension.
What this interaction means in plain words
Naproxen and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Nebivolol belongs to Cardiovascular.
Why it happens
NSAIDs inhibit vasodilatory prostaglandins and cause sodium and fluid retention, opposing beta-blocker effects.
What to do
Monitor blood pressure when naproxen is used regularly and adjust antihypertensive therapy if needed. Prefer the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Naproxen with Nebivolol?
MediHelp rates the interaction as moderate. Naproxen and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen may weaken the antihypertensive effect of nebivolol, particularly with sustained use. The effect is usually modest but can be relevant in poorly controlled hypertension.
How serious is the interaction between Naproxen and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when naproxen is used regularly and adjust antihypertensive therapy if needed. Prefer the lowest effective NSAID dose for the shortest time.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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