Drug interactions
Naproxen + Oxaprozin
Severity: Major
Naproxen and Oxaprozin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of two NSAIDs increases the risk of gastrointestinal ulceration and bleeding and renal injury without extra benefit. Fluid retention and hyperkalemia may also be more likely.
What this interaction means in plain words
Naproxen and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Naproxen belongs to Musculoskeletal; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition duplicates gastric, platelet and renal effects.
What to do
Avoid combining; use a single NSAID at the lowest effective dose with gastroprotection if indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Naproxen with Oxaprozin?
MediHelp rates the interaction as major. Naproxen and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use of two NSAIDs increases the risk of gastrointestinal ulceration and bleeding and renal injury without extra benefit. Fluid retention and hyperkalemia may also be more likely.
How serious is the interaction between Naproxen and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use a single NSAID at the lowest effective dose with gastroprotection if indicated.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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