Drug interactions
Naproxen + Pralatrexate
Severity: Major
Naproxen and Pralatrexate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen may slow pralatrexate elimination, raising exposure and the risk of toxicity such as mucositis and myelosuppression. Renal impairment increases the concern.
What this interaction means in plain words
Naproxen and Pralatrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Naproxen belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
Why it happens
NSAIDs reduce renal blood flow and compete for renal tubular secretion, decreasing pralatrexate clearance.
What to do
Avoid NSAIDs where possible; if needed, monitor renal function and for mucositis and blood count changes, adjusting pralatrexate dose accordingly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Naproxen and Pralatrexate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Naproxen with Pralatrexate?
MediHelp rates the interaction as major. Naproxen and Pralatrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Naproxen may slow pralatrexate elimination, raising exposure and the risk of toxicity such as mucositis and myelosuppression. Renal impairment increases the concern.
How serious is the interaction between Naproxen and Pralatrexate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible; if needed, monitor renal function and for mucositis and blood count changes, adjusting pralatrexate dose accordingly.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
