Drug interactions
Naproxen + Prasugrel
Severity: Major
Naproxen and Prasugrel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen adds to the antiplatelet effect of prasugrel and irritates the gastric mucosa, which increases the risk of serious gastrointestinal and other bleeding. Prasugrel already carries a substantial bleeding risk.
What this interaction means in plain words
Naproxen and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Naproxen belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Additive platelet inhibition (P2Y12 blockade plus reversible COX-1 inhibition) with NSAID-induced mucosal injury.
What to do
Avoid regular NSAID use with prasugrel; use paracetamol for analgesia where possible. If an NSAID is essential, use the shortest course with gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Naproxen with Prasugrel?
MediHelp rates the interaction as major. Naproxen and Prasugrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Naproxen adds to the antiplatelet effect of prasugrel and irritates the gastric mucosa, which increases the risk of serious gastrointestinal and other bleeding. Prasugrel already carries a substantial bleeding risk.
How serious is the interaction between Naproxen and Prasugrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with prasugrel; use paracetamol for analgesia where possible. If an NSAID is essential, use the shortest course with gastroprotection and monitor for bleeding.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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