Drug interactions
Naproxen + Probenecid
Severity: Moderate
Naproxen and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces naproxen elimination, increasing naproxen exposure and the risk of NSAID adverse effects such as GI irritation and renal effects. Naproxen is not expected to meaningfully change probenecid action.
What this interaction means in plain words
Naproxen and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular organic anion transport and glucuronidation of naproxen, lowering its clearance.
What to do
Use the lowest effective naproxen dose and monitor for GI and renal adverse effects. Consider reducing the naproxen dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Naproxen with Probenecid?
MediHelp rates the interaction as moderate. Naproxen and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces naproxen elimination, increasing naproxen exposure and the risk of NSAID adverse effects such as GI irritation and renal effects. Naproxen is not expected to meaningfully change probenecid action.
How serious is the interaction between Naproxen and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective naproxen dose and monitor for GI and renal adverse effects. Consider reducing the naproxen dose if toxicity appears.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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