Drug interactions
Naproxen + Sparsentan
Severity: Major
Naproxen and Sparsentan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan blocks endothelin and angiotensin II receptors, which lowers glomerular pressure, while NSAIDs constrict the afferent arteriole. Combined use can reduce glomerular filtration and cause acute kidney injury, particularly with volume depletion. NSAIDs may also blunt its antihypertensive effect.
What this interaction means in plain words
Naproxen and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Naproxen belongs to Musculoskeletal; Sparsentan belongs to Genitourinary.
Why it happens
NSAID inhibition of vasodilatory prostaglandins combined with sparsentan-mediated efferent arteriolar dilation reduces glomerular filtration.
What to do
Avoid regular NSAID use in patients on sparsentan and use alternative analgesics such as paracetamol. If an NSAID is unavoidable, use the shortest course and monitor creatinine, potassium and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Naproxen with Sparsentan?
MediHelp rates the interaction as major. Naproxen and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sparsentan blocks endothelin and angiotensin II receptors, which lowers glomerular pressure, while NSAIDs constrict the afferent arteriole. Combined use can reduce glomerular filtration and cause acute kidney injury, particularly with volume depletion. NSAIDs may also blunt its antihypertensive effect.
How serious is the interaction between Naproxen and Sparsentan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use in patients on sparsentan and use alternative analgesics such as paracetamol. If an NSAID is unavoidable, use the shortest course and monitor creatinine, potassium and blood pressure.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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