Drug interactions
Naproxen + Tolazamide
Severity: Moderate
Naproxen and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose-lowering effect of sulfonylureas, with a risk of hypoglycemia. The effect is variable and mainly reported with highly protein-bound NSAIDs.
What this interaction means in plain words
Naproxen and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naproxen belongs to Musculoskeletal; Tolazamide belongs to Endocrine.
Why it happens
Possible displacement of the sulfonylurea from plasma protein binding and reduced renal elimination; NSAID-related prostaglandin effects on insulin secretion may contribute.
What to do
Monitor blood glucose when naproxen is started or stopped, and counsel on hypoglycemia symptoms. Reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Naproxen with Tolazamide?
MediHelp rates the interaction as moderate. Naproxen and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose-lowering effect of sulfonylureas, with a risk of hypoglycemia. The effect is variable and mainly reported with highly protein-bound NSAIDs.
How serious is the interaction between Naproxen and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when naproxen is started or stopped, and counsel on hypoglycemia symptoms. Reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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