Drug interactions
Naratriptan + Nortriptyline
Severity: Moderate
Naratriptan and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs increase serotonergic activity, so serotonin syndrome is a low but possible risk. Most patients tolerate the pair, but toxicity can be serious.
What this interaction means in plain words
Naratriptan and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naratriptan belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive serotonergic effect from tricyclic reuptake inhibition and 5-HT1B/1D agonism.
What to do
Monitor for agitation, tremor, sweating and hyperthermia after starting or increasing doses. Stop the triptan if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Nortriptyline?
MediHelp rates the interaction as moderate. Naratriptan and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs increase serotonergic activity, so serotonin syndrome is a low but possible risk. Most patients tolerate the pair, but toxicity can be serious.
How serious is the interaction between Naratriptan and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, sweating and hyperthermia after starting or increasing doses. Stop the triptan if serotonin syndrome is suspected.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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