Drug interactions
Naratriptan + Rasagiline
Severity: Moderate
Naratriptan and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both have serotonergic activity, raising a theoretical risk of serotonin syndrome. Naratriptan is not mainly metabolized by MAO-A, so exposure changes are unlikely.
What this interaction means in plain words
Naratriptan and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naratriptan belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Additive serotonergic effects; limited pharmacokinetic interaction.
What to do
Use the lowest effective naratriptan dose and monitor for serotonin toxicity features. Switch to a non-serotonergic option if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Rasagiline?
MediHelp rates the interaction as moderate. Naratriptan and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both have serotonergic activity, raising a theoretical risk of serotonin syndrome. Naratriptan is not mainly metabolized by MAO-A, so exposure changes are unlikely.
How serious is the interaction between Naratriptan and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective naratriptan dose and monitor for serotonin toxicity features. Switch to a non-serotonergic option if symptoms occur.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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