Drug interactions
Naratriptan + Selegiline
Severity: Moderate
Naratriptan and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining naratriptan with an MAO inhibitor raises a theoretical risk of serotonin syndrome. Naratriptan is not mainly cleared by MAO-A, so exposure changes are not expected.
What this interaction means in plain words
Naratriptan and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Naratriptan belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Additive serotonergic effects.
What to do
Use the lowest effective doses and monitor for agitation, tremor, sweating and hyperthermia. Avoid with higher-dose selegiline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Naratriptan with Selegiline?
MediHelp rates the interaction as moderate. Naratriptan and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining naratriptan with an MAO inhibitor raises a theoretical risk of serotonin syndrome. Naratriptan is not mainly cleared by MAO-A, so exposure changes are not expected.
How serious is the interaction between Naratriptan and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for agitation, tremor, sweating and hyperthermia. Avoid with higher-dose selegiline.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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