Drug interactions
Natalizumab + Trastuzumab
Severity: Moderate
Natalizumab and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab increases neutropenia risk when given with chemotherapy, and natalizumab suppresses immune surveillance. Combined use may raise the risk of infection, although direct data are limited.
What this interaction means in plain words
Natalizumab and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Natalizumab belongs to Gastrointestinal Tract; Trastuzumab belongs to Oncology.
Why it happens
Additive effects on immune defence; trastuzumab adds to neutropenia in combination regimens while natalizumab impairs leukocyte trafficking.
What to do
Monitor for infection and check neutrophil counts if given with chemotherapy. Avoid unless the oncologic benefit is clear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Natalizumab and Trastuzumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Natalizumab
- Natalizumab + Vedolizumab Contraindicated
- Axicabtagene ciloleucel + Natalizumab Major
- Baricitinib + Natalizumab Major
- Belatacept + Natalizumab Major
- Brexucabtagene autoleucel + Natalizumab Major
- Cabazitaxel + Natalizumab Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Natalizumab with Trastuzumab?
MediHelp rates the interaction as moderate. Natalizumab and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab increases neutropenia risk when given with chemotherapy, and natalizumab suppresses immune surveillance. Combined use may raise the risk of infection, although direct data are limited.
How serious is the interaction between Natalizumab and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and check neutrophil counts if given with chemotherapy. Avoid unless the oncologic benefit is clear.
What other medicines interact with Natalizumab?
MediHelp also lists interactions of Natalizumab with, for example, Vedolizumab, Axicabtagene ciloleucel, Baricitinib. The full list is on the Natalizumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
