Drug interactions
Nateglinide + Rifapentine
Severity: Moderate
Nateglinide and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP2C9 and CYP3A4 and can reduce the plasma concentrations of nateglinide. Loss of glucose control is possible during treatment.
What this interaction means in plain words
Nateglinide and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nateglinide belongs to Endocrine; Rifapentine belongs to Anti Bacterial.
Why it happens
Induction of CYP2C9 and CYP3A4 increases nateglinide metabolism.
What to do
Check blood glucose frequently during and after rifapentine therapy and increase the nateglinide dose or change therapy if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Nateglinide with Rifapentine?
MediHelp rates the interaction as moderate. Nateglinide and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP2C9 and CYP3A4 and can reduce the plasma concentrations of nateglinide. Loss of glucose control is possible during treatment.
How serious is the interaction between Nateglinide and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose frequently during and after rifapentine therapy and increase the nateglinide dose or change therapy if control is inadequate.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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