Drug interactions
Nateglinide + Ritonavir
Severity: Moderate
Nateglinide and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is associated with insulin resistance and hyperglycemia, which can undermine the effect of nateglinide. Ritonavir also inhibits CYP3A4, but the net clinical effect is mainly worsened glycemic control.
What this interaction means in plain words
Nateglinide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nateglinide belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Pharmacodynamic antagonism via protease inhibitor-induced insulin resistance.
What to do
Monitor blood glucose and HbA1c after starting ritonavir and intensify antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Nateglinide with Ritonavir?
MediHelp rates the interaction as moderate. Nateglinide and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir is associated with insulin resistance and hyperglycemia, which can undermine the effect of nateglinide. Ritonavir also inhibits CYP3A4, but the net clinical effect is mainly worsened glycemic control.
How serious is the interaction between Nateglinide and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting ritonavir and intensify antidiabetic therapy if needed.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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