Drug interactions
Nateglinide + Secobarbital
Severity: Moderate
Nateglinide and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may reduce nateglinide concentrations, potentially weakening glycemic control. The effect is probably modest but may be relevant with long-term barbiturate use.
What this interaction means in plain words
Nateglinide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nateglinide belongs to Endocrine; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturates induce hepatic CYP2C9 and CYP3A4, increasing nateglinide metabolism.
What to do
Monitor blood glucose and HbA1c when starting or stopping the barbiturate. Increase the nateglinide dose if glycemic control worsens, and reduce it again when the barbiturate is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Nateglinide with Secobarbital?
MediHelp rates the interaction as moderate. Nateglinide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may reduce nateglinide concentrations, potentially weakening glycemic control. The effect is probably modest but may be relevant with long-term barbiturate use.
How serious is the interaction between Nateglinide and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or stopping the barbiturate. Increase the nateglinide dose if glycemic control worsens, and reduce it again when the barbiturate is withdrawn.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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