Drug interactions
Nateglinide + Tolbutamide
Severity: Moderate
Nateglinide and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs stimulate insulin secretion, so combining them adds to hypoglycemia risk and is generally duplicative therapy. Nateglinide is a CYP2C9 substrate and a weak inhibitor, so a small pharmacokinetic effect on tolbutamide is also possible.
What this interaction means in plain words
Nateglinide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nateglinide belongs to Endocrine; Tolbutamide belongs to Endocrine.
Why it happens
Additive insulin secretagogue effects, with possible minor CYP2C9 competition.
What to do
Avoid using both insulin secretagogues together where possible; if combined, monitor blood glucose closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Nateglinide with Tolbutamide?
MediHelp rates the interaction as moderate. Nateglinide and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs stimulate insulin secretion, so combining them adds to hypoglycemia risk and is generally duplicative therapy. Nateglinide is a CYP2C9 substrate and a weak inhibitor, so a small pharmacokinetic effect on tolbutamide is also possible.
How serious is the interaction between Nateglinide and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both insulin secretagogues together where possible; if combined, monitor blood glucose closely.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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