Drug interactions
Nateglinide + Valproic acid
Severity: Minor
Nateglinide and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproic acid can inhibit CYP2C9 weakly, and nateglinide is partly cleared by CYP2C9. Nateglinide exposure could rise slightly, increasing the risk of hypoglycemia, but the effect is expected to be small.
What this interaction means in plain words
Nateglinide and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nateglinide belongs to Endocrine; Valproic acid belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2C9-mediated nateglinide metabolism.
What to do
Monitor blood glucose when starting or stopping valproate and adjust nateglinide if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Nateglinide with Valproic acid?
MediHelp rates the interaction as minor. Nateglinide and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valproic acid can inhibit CYP2C9 weakly, and nateglinide is partly cleared by CYP2C9. Nateglinide exposure could rise slightly, increasing the risk of hypoglycemia, but the effect is expected to be small.
How serious is the interaction between Nateglinide and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping valproate and adjust nateglinide if hypoglycemia occurs.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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