Drug interactions
Nebivolol + Oxymetazoline
Severity: Minor
Nebivolol and Oxymetazoline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymetazoline's alpha-agonist vasoconstriction opposes the blood-pressure-lowering and heart-rate effects of nebivolol in theory. Intranasal systemic exposure is low, so a clinically important effect is unlikely.
What this interaction means in plain words
Nebivolol and Oxymetazoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nebivolol belongs to Cardiovascular; Oxymetazoline belongs to Respiratory.
Why it happens
Opposing adrenergic pharmacodynamics between an alpha-agonist and a beta-1 selective blocker.
What to do
No routine adjustment is needed; check blood pressure if oxymetazoline is used often.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxymetazoline
- Isocarboxazid + Oxymetazoline Major
- Oxymetazoline + Phenelzine Major
- Oxymetazoline + Tranylcypromine Major
- Amitriptyline + Oxymetazoline Moderate
- Amoxapine + Oxymetazoline Moderate
- Clomipramine + Oxymetazoline Moderate
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Oxymetazoline?
MediHelp rates the interaction as minor. Nebivolol and Oxymetazoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxymetazoline's alpha-agonist vasoconstriction opposes the blood-pressure-lowering and heart-rate effects of nebivolol in theory. Intranasal systemic exposure is low, so a clinically important effect is unlikely.
How serious is the interaction between Nebivolol and Oxymetazoline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; check blood pressure if oxymetazoline is used often.
What other medicines interact with Oxymetazoline?
MediHelp also lists interactions of Oxymetazoline with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Oxymetazoline page.
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