Drug interactions
Nebivolol + Primidone
Severity: Moderate
Nebivolol and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is partly converted to phenobarbital and induces hepatic enzymes, which may lower nebivolol exposure and reduce its effect. Loss of blood pressure or heart rate control may follow.
What this interaction means in plain words
Nebivolol and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Primidone belongs to Central Nervous System.
Why it happens
Enzyme induction by primidone and its metabolite phenobarbital increases nebivolol clearance.
What to do
Monitor blood pressure and heart rate, and increase nebivolol dose if response is inadequate. Re-evaluate dose if primidone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Nebivolol with Primidone?
MediHelp rates the interaction as moderate. Nebivolol and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is partly converted to phenobarbital and induces hepatic enzymes, which may lower nebivolol exposure and reduce its effect. Loss of blood pressure or heart rate control may follow.
How serious is the interaction between Nebivolol and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and increase nebivolol dose if response is inadequate. Re-evaluate dose if primidone is stopped.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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