Drug interactions
Nebivolol + Salmeterol
Severity: Moderate
Nebivolol and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol is a highly beta-1 selective blocker, but it can still blunt the response to salmeterol and may trigger bronchospasm in patients with reactive airways, especially at higher doses. The risk is lower than with nonselective beta-blockers.
What this interaction means in plain words
Nebivolol and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-adrenergic receptors, with reduced selectivity at higher nebivolol doses.
What to do
Use the lowest effective nebivolol dose and monitor respiratory symptoms and lung function in patients with asthma or COPD.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Salmeterol?
MediHelp rates the interaction as moderate. Nebivolol and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nebivolol is a highly beta-1 selective blocker, but it can still blunt the response to salmeterol and may trigger bronchospasm in patients with reactive airways, especially at higher doses. The risk is lower than with nonselective beta-blockers.
How serious is the interaction between Nebivolol and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective nebivolol dose and monitor respiratory symptoms and lung function in patients with asthma or COPD.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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