Drug interactions
Nebivolol + Tadalafil
Severity: Minor
Nebivolol and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol is a beta blocker with nitric oxide-mediated vasodilating activity, so tadalafil may add to its blood pressure lowering. Mild to moderate hypotension with dizziness is possible.
What this interaction means in plain words
Nebivolol and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nebivolol belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition and nebivolol's nitric oxide-related effects with beta blockade.
What to do
No routine dose change is needed. Monitor blood pressure at initiation and counsel on orthostatic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Tadalafil?
MediHelp rates the interaction as minor. Nebivolol and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nebivolol is a beta blocker with nitric oxide-mediated vasodilating activity, so tadalafil may add to its blood pressure lowering. Mild to moderate hypotension with dizziness is possible.
How serious is the interaction between Nebivolol and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood pressure at initiation and counsel on orthostatic symptoms.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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