Drug interactions
Nebivolol + Timolol
Severity: Moderate
Nebivolol and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic timolol, including absorption from eye drops, adds to the beta-blockade of nebivolol. The combination can produce bradycardia, hypotension, and AV conduction disturbances.
What this interaction means in plain words
Nebivolol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive beta-adrenergic receptor blockade.
What to do
Avoid oral duplication of beta-blockers. If timolol eye drops are needed, monitor heart rate and blood pressure and consider a non-beta-blocker glaucoma agent in patients with bradycardia or heart block.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Frequently asked questions
Can I take Nebivolol with Timolol?
MediHelp rates the interaction as moderate. Nebivolol and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic timolol, including absorption from eye drops, adds to the beta-blockade of nebivolol. The combination can produce bradycardia, hypotension, and AV conduction disturbances.
How serious is the interaction between Nebivolol and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral duplication of beta-blockers. If timolol eye drops are needed, monitor heart rate and blood pressure and consider a non-beta-blocker glaucoma agent in patients with bradycardia or heart block.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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