Drug interactions
Nefazodone + Paliperidone
Severity: Minor
Nefazodone and Paliperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits P-glycoprotein and CYP3A4 and may modestly raise paliperidone levels, though paliperidone has limited CYP metabolism. Increased adverse effects such as sedation or QT effects are possible but unlikely to be large.
What this interaction means in plain words
Nefazodone and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of P-glycoprotein-mediated paliperidone efflux.
What to do
Monitor for sedation, orthostatic hypotension and extrapyramidal symptoms, and adjust the paliperidone dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Nefazodone with Paliperidone?
MediHelp rates the interaction as minor. Nefazodone and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nefazodone inhibits P-glycoprotein and CYP3A4 and may modestly raise paliperidone levels, though paliperidone has limited CYP metabolism. Increased adverse effects such as sedation or QT effects are possible but unlikely to be large.
How serious is the interaction between Nefazodone and Paliperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and extrapyramidal symptoms, and adjust the paliperidone dose if needed.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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