Drug interactions
Nefazodone + Pentazocine
Severity: Moderate
Nefazodone and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity and pentazocine may add to it, which could increase the risk of serotonin syndrome. Nefazodone also inhibits CYP3A4, which may increase exposure to some opioids, though the effect on pentazocine is uncertain.
What this interaction means in plain words
Nefazodone and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects; nefazodone is also a CYP3A4 inhibitor.
What to do
Monitor for signs of serotonin syndrome and excess sedation, particularly when starting or increasing doses. Reduce the opioid dose or change therapy if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Frequently asked questions
Can I take Nefazodone with Pentazocine?
MediHelp rates the interaction as moderate. Nefazodone and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has serotonergic activity and pentazocine may add to it, which could increase the risk of serotonin syndrome. Nefazodone also inhibits CYP3A4, which may increase exposure to some opioids, though the effect on pentazocine is uncertain.
How serious is the interaction between Nefazodone and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin syndrome and excess sedation, particularly when starting or increasing doses. Reduce the opioid dose or change therapy if toxicity occurs.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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