Drug interactions
Nefazodone + Solifenacin
Severity: Major
Nefazodone and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a strong CYP3A4 inhibitor and can substantially raise solifenacin concentrations. This increases the risk of anticholinergic toxicity and QT prolongation.
What this interaction means in plain words
Nefazodone and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Strong CYP3A4 inhibition reduces solifenacin metabolism.
What to do
Limit solifenacin to 5 mg daily or less and monitor for anticholinergic effects. Consider an alternative antidepressant or bladder agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Nefazodone with Solifenacin?
MediHelp rates the interaction as major. Nefazodone and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nefazodone is a strong CYP3A4 inhibitor and can substantially raise solifenacin concentrations. This increases the risk of anticholinergic toxicity and QT prolongation.
How serious is the interaction between Nefazodone and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit solifenacin to 5 mg daily or less and monitor for anticholinergic effects. Consider an alternative antidepressant or bladder agent.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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