Drug interactions
Nefazodone + Voriconazole
Severity: Major
Nefazodone and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase nefazodone levels, and nefazodone itself strongly inhibits CYP3A4. Both agents may also prolong QT, so combined use adds to risks of sedation, hypotension and arrhythmia.
What this interaction means in plain words
Nefazodone and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of nefazodone, with possible additive QT effects; nefazodone may reciprocally raise voriconazole exposure.
What to do
Avoid the combination where possible and use an alternative antidepressant. If used, monitor the ECG, electrolytes and tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Nefazodone with Voriconazole?
MediHelp rates the interaction as major. Nefazodone and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole may increase nefazodone levels, and nefazodone itself strongly inhibits CYP3A4. Both agents may also prolong QT, so combined use adds to risks of sedation, hypotension and arrhythmia.
How serious is the interaction between Nefazodone and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative antidepressant. If used, monitor the ECG, electrolytes and tolerability.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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