Drug interactions
Nefazodone + Zolmitriptan
Severity: Moderate
Nefazodone and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits serotonin reuptake, so with zolmitriptan it may rarely cause serotonin syndrome. Nefazodone also inhibits CYP3A4, which is a minor route for zolmitriptan.
What this interaction means in plain words
Nefazodone and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects, with minor possible pharmacokinetic change from CYP3A4 inhibition.
What to do
Monitor for serotonin syndrome, especially at initiation or dose increases. Discontinue the agents if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Nefazodone with Zolmitriptan?
MediHelp rates the interaction as moderate. Nefazodone and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone inhibits serotonin reuptake, so with zolmitriptan it may rarely cause serotonin syndrome. Nefazodone also inhibits CYP3A4, which is a minor route for zolmitriptan.
How serious is the interaction between Nefazodone and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome, especially at initiation or dose increases. Discontinue the agents if toxicity develops.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
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