Drug interactions
Nelfinavir + Prednisone
Severity: Moderate
Nelfinavir and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and may increase prednisolone exposure, though prednisolone is less CYP3A4 dependent than methylprednisolone or dexamethasone. Prolonged coadministration may increase risk of Cushingoid effects and adrenal suppression.
What this interaction means in plain words
Nelfinavir and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nelfinavir belongs to Anti Virals; Prednisone belongs to Endocrine.
Why it happens
Nelfinavir inhibits CYP3A4, reducing prednisolone clearance.
What to do
Use the lowest effective prednisone dose and monitor for corticosteroid excess, such as hyperglycemia and fluid retention. Consider alternative corticosteroids for long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Prednisone?
MediHelp rates the interaction as moderate. Nelfinavir and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and may increase prednisolone exposure, though prednisolone is less CYP3A4 dependent than methylprednisolone or dexamethasone. Prolonged coadministration may increase risk of Cushingoid effects and adrenal suppression.
How serious is the interaction between Nelfinavir and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective prednisone dose and monitor for corticosteroid excess, such as hyperglycemia and fluid retention. Consider alternative corticosteroids for long-term therapy.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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