Drug interactions
Nelfinavir + Saxagliptin-metformin
Severity: Moderate
Nelfinavir and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of metformin.
What this interaction means in plain words
Nelfinavir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nelfinavir belongs to Anti Virals; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Protease inhibitors impair insulin sensitivity and glucose uptake.
What to do
Monitor blood glucose regularly and adjust antidiabetic therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Nelfinavir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of metformin.
How serious is the interaction between Nelfinavir and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly and adjust antidiabetic therapy as required.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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