Drug interactions
Nelfinavir + Sertraline
Severity: Moderate
Nelfinavir and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir may raise sertraline concentrations, increasing serotonergic and other dose-related adverse effects. The effect is probably modest because sertraline is cleared by several pathways.
What this interaction means in plain words
Nelfinavir and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nelfinavir belongs to Anti Virals; Sertraline belongs to Central Nervous System.
Why it happens
Nelfinavir inhibits CYP3A4 (and possibly CYP2C19), which contribute to sertraline metabolism.
What to do
Start sertraline at a low dose and titrate to response. Monitor for nausea, agitation, tremor and signs of serotonin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Sertraline?
MediHelp rates the interaction as moderate. Nelfinavir and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir may raise sertraline concentrations, increasing serotonergic and other dose-related adverse effects. The effect is probably modest because sertraline is cleared by several pathways.
How serious is the interaction between Nelfinavir and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start sertraline at a low dose and titrate to response. Monitor for nausea, agitation, tremor and signs of serotonin toxicity.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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