Drug interactions
Nelfinavir + Sitagliptin
Severity: Moderate
Nelfinavir and Sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir, like other HIV protease inhibitors, may cause insulin resistance and hyperglycemia. This can reduce the effectiveness of sitagliptin.
What this interaction means in plain words
Nelfinavir and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nelfinavir belongs to Anti Virals; Sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through protease inhibitor-induced insulin resistance.
What to do
Monitor blood glucose and HbA1c during antiretroviral therapy. Adjust antidiabetic therapy if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Sitagliptin?
MediHelp rates the interaction as moderate. Nelfinavir and Sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir, like other HIV protease inhibitors, may cause insulin resistance and hyperglycemia. This can reduce the effectiveness of sitagliptin.
How serious is the interaction between Nelfinavir and Sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c during antiretroviral therapy. Adjust antidiabetic therapy if control deteriorates.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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