Drug interactions
Nelfinavir + Terbinafine
Severity: Minor
Nelfinavir and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and may slightly raise terbinafine levels. The clinical significance is expected to be small.
What this interaction means in plain words
Nelfinavir and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nelfinavir belongs to Anti Virals; Terbinafine belongs to Anti Fungals.
Why it happens
Nelfinavir inhibits CYP3A4, a minor pathway of terbinafine metabolism.
What to do
No routine dose change is required. Monitor for terbinafine adverse effects over longer courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Terbinafine?
MediHelp rates the interaction as minor. Nelfinavir and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nelfinavir inhibits CYP3A4 and may slightly raise terbinafine levels. The clinical significance is expected to be small.
How serious is the interaction between Nelfinavir and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required. Monitor for terbinafine adverse effects over longer courses.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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