Drug interactions
Nelfinavir + Tinidazole
Severity: Minor
Nelfinavir and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and may reduce the metabolism of tinidazole, raising its levels. This can increase dose-related adverse effects, but short courses are usually tolerated.
What this interaction means in plain words
Nelfinavir and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nelfinavir belongs to Anti Virals; Tinidazole belongs to Anti Parasitic.
Why it happens
Nelfinavir inhibits CYP3A4, decreasing tinidazole clearance.
What to do
No empirical dose change is generally required. Monitor for gastrointestinal and neurological adverse effects, particularly with extended tinidazole use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Tinidazole?
MediHelp rates the interaction as minor. Nelfinavir and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nelfinavir inhibits CYP3A4 and may reduce the metabolism of tinidazole, raising its levels. This can increase dose-related adverse effects, but short courses are usually tolerated.
How serious is the interaction between Nelfinavir and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is generally required. Monitor for gastrointestinal and neurological adverse effects, particularly with extended tinidazole use.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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