Drug interactions
Nelfinavir + Zidovudine
Severity: Minor
Nelfinavir and Zidovudine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are used in HIV therapy, and immune reconstitution inflammatory syndrome can occur after effective treatment is started. This reflects immune recovery rather than a pharmacological interaction. Nelfinavir may also modestly lower zidovudine levels.
What this interaction means in plain words
Nelfinavir and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nelfinavir belongs to Anti Virals; Zidovudine belongs to Anti Virals.
Why it happens
Immune reconstitution results from antiretroviral-induced immune recovery, not a specific drug interaction.
What to do
Monitor for new inflammatory or opportunistic infection symptoms after starting therapy. No zidovudine dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Nelfinavir with Zidovudine?
MediHelp rates the interaction as minor. Nelfinavir and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are used in HIV therapy, and immune reconstitution inflammatory syndrome can occur after effective treatment is started. This reflects immune recovery rather than a pharmacological interaction. Nelfinavir may also modestly lower zidovudine levels.
How serious is the interaction between Nelfinavir and Zidovudine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for new inflammatory or opportunistic infection symptoms after starting therapy. No zidovudine dose adjustment is needed.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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