Drug interactions
Neomycin + Sorafenib
Severity: Moderate
Neomycin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
In a study of healthy volunteers, a course of oral neomycin lowered sorafenib exposure substantially. Reduced sorafenib exposure could theoretically lessen antitumour efficacy.
What this interaction means in plain words
Neomycin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Neomycin belongs to Anti Bacterial; Sorafenib belongs to Oncology.
Why it happens
Likely suppression of gut bacteria that contribute to sorafenib enterohepatic recycling (glucuronide deconjugation), though not firmly established.
What to do
Avoid unnecessary concurrent courses of oral neomycin with sorafenib. If neomycin is required, monitor for reduced sorafenib response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Neomycin with Sorafenib?
MediHelp rates the interaction as moderate. Neomycin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. In a study of healthy volunteers, a course of oral neomycin lowered sorafenib exposure substantially. Reduced sorafenib exposure could theoretically lessen antitumour efficacy.
How serious is the interaction between Neomycin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary concurrent courses of oral neomycin with sorafenib. If neomycin is required, monitor for reduced sorafenib response.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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