Drug interactions
Neomycin po + Oxaliplatin
Severity: Minor
Neomycin po and Oxaliplatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed, so systemic nephrotoxicity and ototoxicity are usually minimal unless the gut is damaged or kidney function is impaired. Oxaliplatin is much less nephrotoxic and ototoxic than cisplatin. Clinically meaningful additive toxicity is uncommon.
What this interaction means in plain words
Neomycin po and Oxaliplatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive oto- and nephrotoxicity if neomycin is absorbed systemically.
What to do
Monitor renal function in patients with renal impairment or mucositis receiving both drugs. Report hearing changes promptly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Neomycin po with Oxaliplatin?
MediHelp rates the interaction as minor. Neomycin po and Oxaliplatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed, so systemic nephrotoxicity and ototoxicity are usually minimal unless the gut is damaged or kidney function is impaired. Oxaliplatin is much less nephrotoxic and ototoxic than cisplatin. Clinically meaningful additive toxicity is uncommon.
How serious is the interaction between Neomycin po and Oxaliplatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function in patients with renal impairment or mucositis receiving both drugs. Report hearing changes promptly.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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