Drug interactions
Neomycin po + Piroxicam
Severity: Minor
Neomycin po and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal clearance of aminoglycosides, which mainly matters in preterm neonates receiving systemic aminoglycosides. Oral neomycin is poorly absorbed, so meaningful exposure is unlikely in most patients.
What this interaction means in plain words
Neomycin po and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAID-related reduction in renal prostaglandins and glomerular filtration may slow aminoglycoside elimination.
What to do
No action is needed in typical adult use; monitor renal function if gut permeability is increased or renal impairment is present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Neomycin po with Piroxicam?
MediHelp rates the interaction as minor. Neomycin po and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can reduce renal clearance of aminoglycosides, which mainly matters in preterm neonates receiving systemic aminoglycosides. Oral neomycin is poorly absorbed, so meaningful exposure is unlikely in most patients.
How serious is the interaction between Neomycin po and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed in typical adult use; monitor renal function if gut permeability is increased or renal impairment is present.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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