Drug interactions
Neomycin po + Tacrolimus
Severity: Moderate
Neomycin po and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed, but absorption may increase with damaged bowel mucosa, and additive nephrotoxicity or ototoxicity with tacrolimus is possible. Clinical significance is usually limited with short courses.
What this interaction means in plain words
Neomycin po and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential additive nephrotoxicity from systemically absorbed neomycin and tacrolimus.
What to do
Limit neomycin duration and monitor renal function and tacrolimus levels. Avoid use in patients with gut inflammation or existing renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Neomycin po with Tacrolimus?
MediHelp rates the interaction as moderate. Neomycin po and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral neomycin is poorly absorbed, but absorption may increase with damaged bowel mucosa, and additive nephrotoxicity or ototoxicity with tacrolimus is possible. Clinical significance is usually limited with short courses.
How serious is the interaction between Neomycin po and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit neomycin duration and monitor renal function and tacrolimus levels. Avoid use in patients with gut inflammation or existing renal impairment.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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