Drug interactions
Netupitant-palonosetron + Nicardipine
Severity: Minor
Netupitant-palonosetron and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a weak to moderate CYP3A4 inhibitor and could modestly raise netupitant concentrations. Netupitant is a CYP3A4 substrate, but the expected rise is small and rarely clinically important. Nicardipine itself is a CYP3A4 substrate, and netupitant may in turn raise its levels.
What this interaction means in plain words
Netupitant-palonosetron and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Nicardipine belongs to Cardiovascular.
Why it happens
Nicardipine weakly inhibits CYP3A4, reducing netupitant clearance; netupitant inhibits CYP3A4, which may reduce nicardipine clearance.
What to do
No netupitant dose adjustment is needed. Monitor blood pressure and heart rate for excessive vasodilator effect from nicardipine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Netupitant-palonosetron with Nicardipine?
MediHelp rates the interaction as minor. Netupitant-palonosetron and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine is a weak to moderate CYP3A4 inhibitor and could modestly raise netupitant concentrations. Netupitant is a CYP3A4 substrate, but the expected rise is small and rarely clinically important. Nicardipine itself is a CYP3A4 substrate, and netupitant may in turn raise its levels.
How serious is the interaction between Netupitant-palonosetron and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No netupitant dose adjustment is needed. Monitor blood pressure and heart rate for excessive vasodilator effect from nicardipine.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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