Drug interactions
Netupitant-palonosetron + Quinidine
Severity: Moderate
Netupitant-palonosetron and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a CYP3A4 substrate with some inhibitory activity and may modestly raise netupitant levels. Netupitant, a CYP3A4 inhibitor, may also increase quinidine concentrations, which matters because of quinidine's narrow therapeutic index and QT-prolonging effect.
What this interaction means in plain words
Netupitant-palonosetron and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Netupitant-palonosetron belongs to Gastrointestinal Tract; Quinidine belongs to Anti Parasitic.
Why it happens
Netupitant inhibits CYP3A4, reducing quinidine clearance, and quinidine may marginally reduce netupitant metabolism.
What to do
Monitor ECG and QT interval, and quinidine levels where available. Correct potassium and magnesium before and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Netupitant-palonosetron with Quinidine?
MediHelp rates the interaction as moderate. Netupitant-palonosetron and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is a CYP3A4 substrate with some inhibitory activity and may modestly raise netupitant levels. Netupitant, a CYP3A4 inhibitor, may also increase quinidine concentrations, which matters because of quinidine's narrow therapeutic index and QT-prolonging effect.
How serious is the interaction between Netupitant-palonosetron and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and QT interval, and quinidine levels where available. Correct potassium and magnesium before and during therapy.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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