Drug interactions
Netupitant / palonosetron + Ribociclib
Severity: Moderate
Netupitant / palonosetron and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant is a CYP3A4 substrate and a moderate CYP3A4 inhibitor, so ribociclib may raise its levels and netupitant may raise ribociclib levels. Palonosetron and ribociclib may both have QT effects, increasing the risk of arrhythmia.
What this interaction means in plain words
Netupitant / palonosetron and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bidirectional CYP3A4 inhibition with possible additive QT prolongation.
What to do
Monitor ECG and electrolytes, and consider reducing the ribociclib dose per labeling for CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Netupitant / palonosetron with Ribociclib?
MediHelp rates the interaction as moderate. Netupitant / palonosetron and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant is a CYP3A4 substrate and a moderate CYP3A4 inhibitor, so ribociclib may raise its levels and netupitant may raise ribociclib levels. Palonosetron and ribociclib may both have QT effects, increasing the risk of arrhythmia.
How serious is the interaction between Netupitant / palonosetron and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and consider reducing the ribociclib dose per labeling for CYP3A4 inhibitors.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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