Drug interactions
Netupitant / palonosetron + Rimegepant
Severity: Moderate
Netupitant / palonosetron and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant is a moderate CYP3A4 inhibitor and can raise rimegepant exposure. This may increase the risk of adverse reactions.
What this interaction means in plain words
Netupitant / palonosetron and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of rimegepant by netupitant.
What to do
When used for acute migraine, avoid a second rimegepant dose within 48 hours. No adjustment is needed for preventive use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Frequently asked questions
Can I take Netupitant / palonosetron with Rimegepant?
MediHelp rates the interaction as moderate. Netupitant / palonosetron and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant is a moderate CYP3A4 inhibitor and can raise rimegepant exposure. This may increase the risk of adverse reactions.
How serious is the interaction between Netupitant / palonosetron and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When used for acute migraine, avoid a second rimegepant dose within 48 hours. No adjustment is needed for preventive use.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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